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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. We applied an ensemble of 16 Bayesian models to vital statistics data to estimate the all-cause mortality effect of the pandemic for 21 industrialized countries.
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Savage X Fenty: Why sex still sells in women's fashion

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Sex differences in mood disorders: perspectives from humans and rodent models

Modern fashion has taught us that the line between the empowerment and the objectification of women is a difficult one for brands to tread. With PrettyLittleThing coming under fire from the Advertising Standards Authority for their overly sexualised advertising, consumers are more conscious than ever of companies who use sex appeal to sell to young women. Take the online retailer TechStyle Fashion Group, for example. The singer's clothing business has made waves in the fashion world by calling for inclusivity, diversity and taking fashion into the streaming age by striking a deal with Amazon Prime. And the key to its success has been the way it puts female desire at the forefront, says Olga Mitterfellner, fashion marketing and management lecturer at The London College of Fashion. But it is great to remind the next generation that they have choices, power and control over who they are and want to be.
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Sex differences in mood disorders: perspectives from humans and rodent models

Mood disorders are devastating, often chronic illnesses characterized by low mood, poor affect, and anhedonia. Notably, mood disorders are approximately twice as prevalent in women compared to men. If sex differences in mood are due to underlying biological sex differences, a better understanding of the biology is warranted to develop better treatment or even prevention of these debilitating disorders. In this review, our goals are to: 1 summarize the literature related to mood disorders with respect to sex differences in prevalence, 2 introduce the corticolimbic brain network of mood regulation, 3 discuss strategies and challenges of modeling mood disorders in mice, 4 discuss mechanisms underlying sex differences and how these can be tested in mice, and 5 discuss how our group and others have used a translational approach to investigate mechanisms underlying sex differences in mood disorders in humans and mice. Major depressive disorder MDD is a severe mental illness and the leading cause of disability and of years of productivity lost worldwide [ 1 ].
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